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KMID : 0351619670080020215
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Kyungpook Medical Journal
1967 Volume.8 No. 2 p.215 ~ p.241
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Experimental Study of Effect of Cortisone and Testosterone on Skeletal Growth of Chick Embryos
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Abstract
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924 white Leghorn eggs were incubated and 0. o mg or 2.Omg of cortisone, and 0. omg or 7.5mg of testosterone was injected into 70 growing chick embryos respectively either on the 3th or 12th day of incubation, and the effects of the hormones on the grog, th of the skeletal system of the embryo were studied daily up to the 18th incubation day. Tho effects of tf!e hormones thus obtained wire further analysed by the following formulas in order to clarify the si;nificance of each growth curve.
y =a ´-bt ,pct´
y: growth quantity of the embryo or . skeletal system.
t: specific date of incubation
period.
a, b, c: constants.
The results are summarized as follows:
1) Cortisone in general suppressed the growth ot" rthe chick embryo.
2) When injected with 2.Omg of cortisone, the growth inhibition of the embryos appeared to be stronger than with 0.5mg of cortisone, except in the Jumbo-coccygeal growth in the 3th day group.
3) The gravth inhibition with cortisone in geaerail was relatively more apparent in the 8th day group than in the 12th day group.
4) In the 8th day group, general inhibition of the growth was observed with 7.5mg of testosterone whereas 0, 5mg of testosterone showed a tendency of the growth sti:r_ulation in general anti a significant stimulation in the thoracic ver-tebrae in particular.
5) In the 12th day group, testosterone in general showed no significant evidence of the growth inhibition except in the thoracic vertebrae where an effective inhibition of the growth was observed with the hormone.
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KEYWORD
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